Surface Chemistry is
an essential tool in
Protein and Peptide
chemistry

Protein/Peptide
activity

 
   

EminTech 

 
   
 

Proteins and peptides expose surfaces
that behaves according to principles
known in Surface Chemistry.

In the human body, they interact
with cell surface components.
This interaction is determined by
specific and non- specific factors.

Before specific factors become active,
non-specific factors must already be
functioning. Peptides have to adsorb
at a target structure, and still be in an
active form, before they interact with it.

Surface Chemistry is hence one of the
essential disciplines in determining
protein and peptide activity.
 

 

  For more information
about projects involving peptides, please visit Microbionical.com.

The membrane-binding C2 domain of Factor VIII
in presence of dodecylphosphocholine micelles
[1FAC - Veeraraghavan, S. et al., Biochem. J. 332
(1998) 549-555]. Images by Pymol.
 
   Amino acid color codes
  not polar, hydrophobic
  aromatic hydrophobic
  aromatic hydrophobic polar
  acidic (anionic)
  polar uncharged
  basic, (cationic)
  basic aromatic

 
As seen in the model, the membrane
binding C2 domain of Factor VIII show a
division in hydrophilic and hydrophobic
regions.

The hydrophobic region is a key
factor in the membrane-binding
properties of the domain.

The large hydrophobic surface
of the domain will, in solution,
cause a more spherical shape
compared to the model, or
alternatively, formation of di- or
oligomer aggregates.

 
           
      Product Development EminTech Start Page