Protein/Peptide
activity

In solution, proteins and peptides form
surfaces that behaves according to
principles known in surface chemistry.

Proteins interact with cell surfaces in vivo.
This interaction is determined by specific
and by non-specific factors.

Before the specific factors come into
play, the non-specific factors must be
taken care of.

Results from cooperation with
protein chemists at NOVO-Nordisk
and from consultant projects have
demonstrated that surface chemical
knowledge explains many effects
observed in protein and peptide
formulations
 

 
As seen in the model, the membrane
binding C2 domain of Factor VIII show a
division in hydrophilic and hydrophobic
regions.

The hydrophobic region is probably
responsible for membrane-binding
properties of the domain.

The presence of the large hydrophobic
domain implies that the peptide either forms
a more spherical shape, or will aggregate
into di- or oligomers, in solution.